I had a mast cell protocol before I started a methylation protocol and I believe this was critical for me. Before I was on Hydroxyzine hcl 10 mg at bedtime I didn't have the cognitive function or attention span to grasp methylation. I also believe I would not have tolerated all the sups that I needed because before my mast cell protocol I was very reactive to botanicals. I don't think I would have tolerated all of Dr. Yasko's sups. "Mast cells reside in the CNS and are capabl ... e of migrating across the blood-brain barrier (BBB) in situations where the barrier is compromised as a result of CNS pathology. Mast cells are both sensors and effectors in communication among nervous, vascular, and immune systems. In the brain, they reside on the brain side of the BBB, and interact with astrocytes, microglia, and blood vessels via their neuroactive stored and newly synthesized chemicals. They are first responders, acting as catalysts and recruiters to initiate, amplify, and prolong other immune and nervous responses upon activation. Mast cells both promote deleterious outcomes in brain function and contribute to normative behavioral functioning, particularly cognition and emotion. Mast cells may play a key role in treating systemic inflammation or blockade of signaling pathways from the periphery to the brain." mature ladies wedding apparels in tea length